Leighton, a child patient, playing with her parents

Leighton (Actual Patient) & Her Family

RYLAZE resource library

Downloadable materials to help support completion of the asparaginase journey

Patient Brochure

Find information about acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL), tips, and guidance for treatment with RYLAZE.

Watch to learn more about ALL and LBL, allergic reactions to asparaginase medication, and how RYLAZE works

What are ALL and LBL?, thumbnail

What are ALL and LBL?

Learn about blood cancers known as ALL and LBL.

What is an allergic reaction?, thumbnail

What is an allergic reaction?

Discover the signs and symptoms of allergic reactions.

What is Rylaze?, thumbnail

What is RYLAZE?

Understand how a different asparaginase treatment helps the body continue fighting ALL and LBL.

Find out how others living with ALL and LBL have relied on RYLAZE

Patient experiences: Leighton's story, thumbnail

Patient experiences: Leighton’s story

Meet Leighton, a child treated with RYLAZE, and her family.

Alt text: Patient experiences: Caroline's story, thumbnail

Patient experiences: Caroline’s story

Meet Caroline, a young adult living with ALL who received treatment with RYLAZE.

What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)

Contact your doctor immediately if any of these side effects occur.

Some of the most common side effects with RYLAZE include:

  • Liver problems
  • Nausea and vomiting
  • Bone and muscle pain
  • Infection
  • Tiredness
  • Headache
  • Fever with low white blood cell count
  • Fever
  • Bleeding
  • Mouth swelling (sometimes with sores)
  • Pain in the abdomen
  • Decreased appetite
  • Allergic reactions
  • High blood sugar levels
  • Diarrhea
  • Swelling of the pancreas
  • Low levels of potassium in your blood

RYLAZE can harm your unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or nursing. Females of reproductive potential should use effective contraception (other than hormonal contraceptives) during treatment and for 3 months following the final dose. Do not breastfeed while receiving RYLAZE and for 1 week after the final dose.

Tell your healthcare provider if there are any side effects that are bothersome or that do not go away.

These are not all the possible side effects of RYLAZE. For more information, ask your healthcare provider.

Call your doctor for medical advice about any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

Please see full Prescribing Information and discuss with your doctor.

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What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION & APPROVED USE

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)