Patient experiences: Leighton’s story

Meet Leighton, a child treated with RYLAZE, and her family.

Hi Leighton. Thank you so much for joining us today. Can you tell me who you’re sitting next to?

Momma and Dadda.

That’s right. What are you holding?

My stuffie.

Does your stuffie have something special about it?

Yes, because he has a port, he has an access just like me.

He does, that’s amazing. Does your doggy get special medicine just like you, too?

Yes.

Can you show me how he gets medicine the way you do?

Woop! Like that.

I think obviously from day 1 it was a huge impact. Here we are sitting in this little tiny room in the emergency department, and discussing treatment for our daughter’s leukemia.

I think when we found that Leighton was allergic to the drug, that was the first time in treatment that we really hit a fork in the road.

After I realized that she had this reaction and this drug wasn’t going to work moving forward, I think I felt really defeated.

Up until then, we’d been hitting our milestones. This was the first time that we really had a situation where the treatment wasn’t working and we had to make a decision and talk about clinical drugs.

We knew that we had to find a way for her to get the medication somehow.

When we found that we had the option of, to join the clinical trial, it made me feel so happy that there was something else out there and there was another avenue that we can explore to make sure that Leighton gets the treatment that her little body needed.

To have it available to us, we were so grateful and we’re forever grateful.

How many more pokes do you have after this?

Zero!

What? This is your last one?

Yes and then next time I come to clinic, I’m going to be 5 years old. My birthday’s pretty soon.

Wow.

Number 1 thing that’s made this easy for us is Leighton, by far. We’re the luckiest parents in the world to have her as a daughter.

I strongly believe that instilling positivity in her and her mind and strength and courage has helped her and will help her down the road beat this and just be stronger because of it.

What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)

Contact your doctor immediately if any of these side effects occur.

Some of the most common side effects with RYLAZE include:

  • Liver problems
  • Nausea and vomiting
  • Bone and muscle pain
  • Infection
  • Tiredness
  • Headache
  • Fever with low white blood cell count
  • Fever
  • Bleeding
  • Mouth swelling (sometimes with sores)
  • Pain in the abdomen
  • Decreased appetite
  • Allergic reactions
  • High blood sugar levels
  • Diarrhea
  • Swelling of the pancreas
  • Low levels of potassium in your blood

RYLAZE can harm your unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or nursing. Females of reproductive potential should use effective contraception (other than hormonal contraceptives) during treatment and for 3 months following the final dose. Do not breastfeed while receiving RYLAZE and for 1 week after the final dose.

Tell your healthcare provider if there are any side effects that are bothersome or that do not go away.

These are not all the possible side effects of RYLAZE. For more information, ask your healthcare provider.

Call your doctor for medical advice about any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

Please see full Prescribing Information and discuss with your doctor.

What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION & APPROVED USE

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)
Jazz Pharmaceuticals logo Up Arrow

RYLAZE is a registered trademark of Jazz Pharmaceuticals Ireland Limited.

All other trademarks are the property of their respective owners.

©2023 Jazz Pharmaceuticals, Inc.   US-ASN-2300006   Rev0524

This site is intended for US residents only.