Patient experiences: Caroline’s story

Meet Caroline, a young adult living with acute lymphoblastic leukemia (ALL) who received treatment with RYLAZE.

I think sometimes it's easy to take for granted how easy it is just to breathe. But when you can't breathe, living every moment is just so difficult because it's such an essential life function.

I was walking home from a Christmas potluck with my fellow teachers. Crossing the bridge over the street coming back, you have to go up lots of stairs and I all of a sudden just had a breathing attack out of nowhere. I couldn't catch my breath. One of my teachers had to come help me.

So, they decided the next step was because I had fluid not only in my lungs, it was in the sac around my heart, the pericardial sac that they needed to drain it from around there.

When they first looked at my biopsy of the heart area and around the lymph nodes, they could see okay, my lymph nodes were cancerous, they were malignant, and they diagnosed me with lymphoma. When they did a PET scan as well as a bone marrow biopsy to really confirm the extent of my cancer, this is when they figured out that it wasn't just in my lymph nodes, it was also in my bone marrow. And I was diagnosed with acute lymphoblastic lymphoma and leukemia.

When I found out I was diagnosed with T-cell ALL, it was very unique because here T-cells are my specialty and I've been diagnosed with this rare form of ALL, and it's, yeah, it was something that I'm familiar with and it helped me to understand what I was going through.

Four months into my diagnosis, I had a reaction to PEG for the first time.

It started with an itchy feeling, and it progressed to kind of my throat closing up.

I don't think I realized how serious it was that I didn't have an alternative.

And at this point, not only is it adversely affecting me, so I can't receive it, but even if I could, my body wouldn't be able to use it in the correct manner, so I need some other drug to achieve the same effect. And this is when we had to figure out what do I do? How can I continue to receive my treatment fully and effectively?

For me, RYLAZE didn't add any noticeable symptoms to what I was currently experiencing from all my other chemos.

Family is what's been keeping me positive through this process. It's been the doctors and my family and it's really what's been keeping me going.

I'm so glad I was able to participate in the trial and receive RYLAZE. It meant all the world to be able to finish my treatment and know that I did everything that I possibly could and with our current knowledge, so that I would be healthy, and you know hopefully not have a relapse. And I was able to do that because of RYLAZE.

What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)

Contact your doctor immediately if any of these side effects occur.

Some of the most common side effects with RYLAZE include:

  • Liver problems
  • Nausea and vomiting
  • Bone and muscle pain
  • Infection
  • Tiredness
  • Headache
  • Fever with low white blood cell count
  • Fever
  • Bleeding
  • Mouth swelling (sometimes with sores)
  • Pain in the abdomen
  • Decreased appetite
  • Allergic reactions
  • High blood sugar levels
  • Diarrhea
  • Swelling of the pancreas
  • Low levels of potassium in your blood

RYLAZE can harm your unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or nursing. Females of reproductive potential should use effective contraception (other than hormonal contraceptives) during treatment and for 3 months following the final dose. Do not breastfeed while receiving RYLAZE and for 1 week after the final dose.

Tell your healthcare provider if there are any side effects that are bothersome or that do not go away.

These are not all the possible side effects of RYLAZE. For more information, ask your healthcare provider.

Call your doctor for medical advice about any side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

Please see full Prescribing Information and discuss with your doctor.

What is RYLAZE?

RYLAZE is a prescription medicine, given by intramuscular injection, that is part of a chemotherapy regimen used to treat adults and children 1 month or older who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection, and lymphoblastic lymphoma (LBL), a type of non-Hodgkin lymphoma that also affects white blood cells. RYLAZE is used in patients who have had an allergic reaction to E. coli asparaginase.

IMPORTANT SAFETY INFORMATION & APPROVED USE

RYLAZE should not be given to people who have:

  • History of serious allergic reactions to RYLAZE
  • History of serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during previous asparaginase treatment
  • Severe damage to the liver

RYLAZE may cause serious side effects, including:

  • Allergic reactions (a feeling of tightness in your throat, unusual swelling/redness in your throat and/or tongue, rash, or trouble breathing), some of which may be life-threatening
  • Swelling of the pancreas (stomach pain), which, if left untreated, may be fatal
  • Blood clots (may be experienced as headache, arm or leg swelling, shortness of breath, or chest pain), which may be life-threatening
  • Bleeding, which may be life-threatening
  • Liver problems (may result in abnormal laboratory values) or, in severe cases, hepatic veno-occlusive disease (reduced blood flow in the liver)